|Other Names||LIM and SH3 domain protein 1, LASP-1, Metastatic lymph node gene 50 protein, MLN 50, LASP1, MLN50|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).|
|Cellular Location||Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note=Associated with the F- actin rich cortical cytoskeleton.|
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This gene encodes a member of a LIM protein subfamilycharacterized by a LIM motif and a domain of Src homology region 3.The encoded protein functions as an actin-binding protein andpossibly in cytoskeletal organization.
Traenka, C., et al. Cancer Res. 70(20):8003-8014(2010)Zhao, L., et al. FEBS J. 277(20):4195-4204(2010)Zhao, L., et al. Gut 59(9):1226-1235(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Frietsch, J.J., et al. Br. J. Cancer 102(11):1645-1653(2010)
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