|Other Names||Protein CREG1, Cellular repressor of E1A-stimulated genes 1, CREG1, CREG|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.|
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The adenovirus E1A protein both activates and repressesgene expression to promote cellular proliferation and inhibitdifferentiation. The protein encoded by this gene antagonizestranscriptional activation and cellular transformation by E1A. Thisprotein shares limited sequence similarity with E1A and binds boththe general transcription factor TBP and the tumor suppressor pRbin vitro. This gene may contribute to the transcriptional controlof cell growth and differentiation.
Han, Y., et al. J. Mol. Cell. Cardiol. 48(6):1225-1235(2010)Ehret, G.B., et al. Eur. J. Hum. Genet. 17(12):1650-1657(2009)Han, Y., et al. Exp. Cell Res. 315(19):3301-3311(2009)Bian, Z., et al. J. Cell. Mol. Med. 13(7):1302-1313(2009)Cheung, C.L., et al. Hum. Mol. Genet. 18(4):679-687(2009)
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