|Other Accession||Q9N077, NP_115542.2|
|Other Names||ATR-interacting protein, ATM and Rad3-related-interacting protein, ATRIP, AGS1|
|Target/Specificity||The synthetic peptide sequence is selected from aa 234-248 of HUMAN ATRIP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.|
|Cellular Location||Nucleus. Note=Redistributes to discrete nuclear foci upon DNA damage|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene is an essential component of the DNA damage checkpoint, and binds to single-stranded DNA coated with replication protein A that accumulates at sites of DNA damage. The encoded protein interacts with the ataxia telangiectasia and Rad3 related protein, a checkpoint kinase, resulting in accumulation of the kinase at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.
Bailey, S.D., et al. Diabetes Care (2010) In press :
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Myers, J.S., et al. Cancer Res. 67(14):6685-6690(2007)
Venere, M., et al. Cancer Res. 67(13):6100-6105(2007)
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