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M TLR4 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9QUK6
Clone Names 2110807
Peptide ID 2110807
Additional Information
Gene ID 21898
Other Names Toll-like receptor 4, CD284, Tlr4, Lps
Target/Specificity The synthetic peptide sequence is selected from aa 39~55 of mouse TLR4.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Tlr4
Synonyms Lps
Function Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:9851930, PubMed:9989976, PubMed:20133493). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:24380872). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid- beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B- dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein Note=Upon complex formation with CD36 and TLR6, internalized through dynamin-dependent endocytosis {ECO:0000250|UniProtKB:O00206}
Tissue Location Highly expressed in heart, spleen, lung and muscle. Lower levels are found in liver and kidney. Expressed in macrophages.
Research Areas
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Background

TLR4, a type I membrane protein that belongs to the Toll-like receptor family, cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). It acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response TLR4 Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR. TLR4 binds to LY96 via the extracellular domain, and to MyD88 and TIRAP via their respective TIR domains. The protein contains 19 leucine-rich (LRR) repeats, and It is highly expressed in heart, spleen, lung and muscle. Lower levels are found in liver and kidney. Interstrain analyses reveal that TLR4 is a polymorphic protein and that the extracellular domain is far more variable than the cytoplasmic domain, which is variable at the C-terminal.

References

Okazaki, Y., et al., Nature 420(6915):563-573 (2002).Rhee, S.H., et al., J. Biol. Chem. 275(44):34035-34040 (2000).Qureshi, S.T., et al., J. Exp. Med. 189(4):615-625 (1999).Underhill, D.M., et al., Nature 401(6755):811-815 (1999).Poltorak, A., et al., Blood Cells Mol. Dis. 24(3):340-355 (1998).

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$ 80.00
Cat# BP1504a
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