|Other Names||Toll-like receptor 8, CD288, TLR8|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1508a was selected from the N-term region of human Human TLR8 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells|
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Provided below are standard protocols that you may find useful for product applications.
TLR8 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR8 is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.
Heil, F., et al., Science 303(5663):1526-1529 (2004).Clark, H.F., et al., Genome Res. 13(10):2265-2270 (2003).Miettinen, M., et al., Genes Immun. 2(6):349-355 (2001).Chuang, T.H., et al., Eur. Cytokine Netw. 11(3):372-378 (2000).Du, X., et al., Eur. Cytokine Netw. 11(3):362-371 (2000).
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