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TLR8 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9NR97
Clone Names 2103135
Additional Information
Gene ID 51311
Other Names Toll-like receptor 8, CD288, TLR8
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1508b was selected from the C-term region of human Human TLR8 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TLR8
Function Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells
Research Areas
Citations (0)

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TLR8 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR8 is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.


Heil, F., et al., Science 303(5663):1526-1529 (2004).Clark, H.F., et al., Genome Res. 13(10):2265-2270 (2003).Miettinen, M., et al., Genes Immun. 2(6):349-355 (2001).Chuang, T.H., et al., Eur. Cytokine Netw. 11(3):372-378 (2000).Du, X., et al., Eur. Cytokine Netw. 11(3):362-371 (2000).

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$ 80.00
Cat# BP1508b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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