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TLR9 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9NR96
Clone Names 2103136
Additional Information
Gene ID 54106
Other Names Toll-like receptor 9, CD289, TLR9
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1509a was selected from the N-term region of human Human TLR9 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TLR9
Function Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection.
Cellular Location Endoplasmic reticulum membrane; Single-pass type I membrane protein Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.
Tissue Location Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre- dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver
Research Areas
Citations (0)

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TLR9 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR9 is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.


Clark, H.F., et al., Genome Res. 13(10):2265-2270 (2003).Bourke, E., et al., Blood 102(3):956-963 (2003).Fenhalls, G., et al., Am. J. Respir. Cell Mol. Biol. 29(1):28-38 (2003).Equils, O., et al., J. Immunol. 170(10):5159-5164 (2003).Gantner, F., et al., Eur. J. Immunol. 33(6):1576-1585 (2003).

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$ 80.00
Cat# BP1509a
(40 western blots)
Availability: In Stock
Bulk Size
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