|Other Names||Gap junction alpha-3 protein, Connexin-46, Cx46, GJA3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1543c was selected from the C-term region of human GJA3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, gap junction|
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GJA3, an integral membrane protein, belong to the connexin family, alpha-type (group II) subfamily. One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. This particular connexin is a component of lens fiber gap junctions, can form both junctional and nonjunctional ('hemi-') channels. Defects in GJA3 are the cause of zonular pulverulent cataract type 3 (CZP3), a form of autosomal dominant congenital cataract.
Mackay, D., et al., Am. J. Hum. Genet. 64(5):1357-1364 (1999).Gong, X., et al., Cell 91(6):833-843 (1997).Mackay, D., et al., Am. J. Hum. Genet. 60(6):1474-1478 (1997).Jiang, H., et al., (er) Mol. Vis. 9, 579-583 (2003) (): ().Bennett, T.M., et al., (er) Mol. Vis. 10, 376-382 (2004) (): ().
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