|Other Names||Gap junction beta-4 protein, Connexin-303, Cx303, GJB4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1544a was selected from the N-term region of human GJB4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, gap junction|
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Gap junctions permit direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular communication. Gap junction channels consist of connexin protein subunits encoded by a multigene family. Erythrokeratodermia variabilis (EKV) is an autosomal dominant disorder of keratinization characterized by migratory erythematous lesions and fixed keratotic plaques. Mutations in the GJB3 gene have been reported in some but not all families, although it has been postulated that the absence of connexin 30.3 can be compensated by other connexins.
Ota, T., et al., Nat. Genet. 36(1):40-45 (2004).Richard, G., et al., J. Invest. Dermatol. 120(4):601-609 (2003).Macari, F., et al., Am. J. Hum. Genet. 67(5):1296-1301 (2000).Lopez-Bigas, N., et al., Hum. Mutat. 19 (4), 458 (2002).
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