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GJB6 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O95452 |
|---|---|
| Clone Names | 2052004 |
| Gene ID | 10804 |
|---|---|
| Other Names | Gap junction beta-6 protein, Connexin-30, Cx30, GJB6 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP1546b was selected from the C-term region of human GJB6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GJB6 |
|---|---|
| Function | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, gap junction |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. I Mutations in GJB2 are associated with genetically derived hearing impairments, including autosomal dominant, bilateral, middle to high frequency hearing loss.
References
Beltramello, M., et al., Biochem. Biophys. Res. Commun. 305(4):1024-1033 (2003).Common, J.E., et al., Biochem. Biophys. Res. Commun. 298(5):651-656 (2002).Smith, F.J., et al., J. Invest. Dermatol. 118(3):530-532 (2002).del Castillo, I., et al., N. Engl. J. Med. 346(4):243-249 (2002).Pallares-Ruiz, N., et al., Eur. J. Hum. Genet. 10(1):72-76 (2002).
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