|Other Names||Gap junction alpha-8 protein, Connexin-50, Cx50, Lens fiber protein MP70, GJA8|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1548a was selected from the N-term region of human GJA8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, gap junction|
|Tissue Location||Eye lens.|
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GJA8 is a an integral membrane protein that belongs to the connexin family, alpha-type (group II) subfamily. One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. This particular connexin only forms junctional channels. GJA8 is expressed in the eye lens, and defects in GJA8 are the cause of zonular pulverulent cataract type 1 (CZP1), a form of autosomal dominant congenital cataract.
Shiels, A., et al., Am. J. Hum. Genet. 62(3):526-532 (1998).Church, R.L., et al., Curr. Eye Res. 14(10):979-981 (1995).Church, R.L., et al., Curr. Eye Res. 14(3):215-221 (1995).
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