Connexin 36 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UKL4 |
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Clone Names | 2052702 |
Gene ID | 57369 |
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Other Names | Gap junction delta-2 protein, Connexin-36, Cx36, Gap junction alpha-9 protein, GJD2, GJA9 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP1549b was selected from the C-term region of human GJA9. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GJD2 |
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Synonyms | GJA9 |
Function | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. |
Cellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, gap junction |
Tissue Location | Highly expressed in neurons. |
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Provided below are standard protocols that you may find useful for product applications.
Background
GJA9, also called connexin-36 (CX36), is a member of the connexin gene family that is expressed predominantly in mammalian neurons. Connexins associate in groups of 6 and are organized radially around a central pore to form connexons. Each gap junction intercellular channel is formed by the conjunction of 2 connexons.
References
de Brouwer, A.P., et al., Hum. Genet. 112(2):156-163 (2003).Belluardo, N., et al., J. Neurosci. Res. 57(5):740-752 (1999).
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