|Other Names||Hippocalcin-like protein 1, Calcium-binding protein BDR-1, HLP2, Visinin-like protein 3, VILIP-3, HPCAL1, BDR1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1563c was selected from the Center region of human VILIP3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.|
|Cellular Location||Membrane; Lipid-anchor|
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VILIP3 is a member of neuron-specific calcium-binding proteins family found in the retina and brain. It is highly similar to human hippocalcin protein and nearly identical to the rat and mouse hippocalcin like-1 proteins. It may be involved in the calcium-dependent regulation of rhodopsin phosphorylation and may be of relevance for neuronal signalling in the central nervous system. There are two alternatively spliced transcript variants of this gene, with multiple polyadenylation sites. Transcript varian 1 utilizes a different exon and also lacks one exon in the 5' UTR, as compared to variant 2; thus, the encoded protein is the same.
Braunewell, K., et al., Dement Geriatr Cogn Disord 12(2):110-116 (2001).Bernstein, H.G., et al., J Neurocytol 28(8):655-662 (1999).Kobayashi, M., et al., Biochim. Biophys. Acta 1222(3):515-518 (1994).Hidaka, H., et al., Neurosci. Res. 16(2):73-77 (1993).Ivings, L., et al., Biochem. J. 363 (Pt 3), 599-608 (2002).
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