|Other Names||Guanylyl cyclase-activating protein 3, GCAP 3, Guanylate cyclase activator 1C, GUCA1C, GCAP3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1569b was selected from the C-term region of human GCAP3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)- sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure.|
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Provided below are standard protocols that you may find useful for product applications.
GCAP3 stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ion concentration is low and inhibits guanylyl cyclases when free calcium ion concentration is elevated This Ca(2+) sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure. GCAP3 contains 4 EF-hand calcium-binding domains and is expressed in the retina.
Haeseleer, F., et al., J. Biol. Chem. 274(10):6526-6535 (1999).
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