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KChIP4 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q6PIL6
Clone Names 2010412
Additional Information
Gene ID 80333
Other Names Kv channel-interacting protein 4, KChIP4, A-type potassium channel modulatory protein 4, Calsenilin-like protein, Potassium channel-interacting protein 4, KCNIP4, CALP, KCHIP4
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1574a was selected from the N-term region of human KChIP4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCNIP4
Synonyms CALP, KCHIP4
Function Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:11847232, PubMed:18957440, PubMed:23576435). Modulates KCND3/Kv4.3 currents (PubMed:23576435). Isoform 4 does not increase KCND2 expression at the cell membrane (PubMed:18957440). Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane.
Cellular Location Cell membrane; Peripheral membrane protein Cytoplasm
Tissue Location Predominantly expressed in brain.
Research Areas
Citations (0)

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Background

KChIP4 is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin.

References

Morohashi, Y., et al., J. Biol. Chem. 277(17):14965-14975 (2002).Holmqvist, M.H., et al., Proc. Natl. Acad. Sci. U.S.A. 99(2):1035-1040 (2002).

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$ 80.00
Cat# BP1574a
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