- CITATIONS: 1
|Other Names||Kinesin-1 heavy chain, Conventional kinesin heavy chain, Ubiquitous kinesin heavy chain, UKHC, KIF5B, KNS, KNS1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1575a was selected from the Central region of human KINH. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes.|
|Cellular Location||Cytoplasm, cytoskeleton. Note=Uniformly distributed between soma and neurites in hippocampal neurons.|
Provided below are standard protocols that you may find useful for product applications.
Kinesins are microtubule-based motor proteins involved in the transport of organelles in eukaryotic cells. They typically consist of 2 identical, approximately 110- to 120-kD heavy chains and 2 identical, approximately 60- to 70-kD light chains. The heavy chain contains 3 domains: a globular N-terminal motor domain, which converts the chemical energy of ATP into a motile force along microtubules in 1 fixed direction; a central alpha-helical rod domain, which enables the 2 heavy chains to dimerize; and a globular C-terminal domain, which interacts with light chains and possibly an organelle receptor.
1. Kamal, A.; et al. Nature 414: 643-648, 2001. 2. Kamal, A.; et al. Neuron 28: 449-459, 2000. 3. Kull, F. J.; et al. Nature 380: 550-555, 1996.
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