|Other Names||Profilin-2, Profilin II, PFN2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.|
|Cellular Location||Cytoplasm, cytoskeleton.|
|Tissue Location||Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver|
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The protein encoded by this gene is a ubiquitous actinmonomer-binding protein belonging to the profilin family. It isthought to regulate actin polymerization in response toextracellular signals. There are two alternatively splicedtranscript variants encoding different isoforms described for thisgene.
Shao, J., et al. Mol. Cell. Biol. 28(17):5196-5208(2008)Rikova, K., et al. Cell 131(6):1190-1203(2007)Xu, J., et al. Cell. Signal. 19(7):1575-1582(2007)Stelzl, U., et al. Cell 122(6):957-968(2005)Lederer, M., et al. J. Cell. Sci. 118 (PT 2), 331-341 (2005) :
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