|Other Names||P2X purinoceptor 2, P2X2, ATP receptor, Purinergic receptor, P2RX2, P2X2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle.|
|Cellular Location||Cell membrane; Multi-pass membrane protein Note=Localizes to the apical membranes of hair cells in the organ of Corti|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the family ofpurinoceptors for ATP. This receptor functions as a ligand-gatedion channel. Binding to ATP mediates synaptic transmission betweenneurons and from neurons to smooth muscle. Six transcript variantsencoding six distinct isoforms have been identified for this gene.
Allsopp, R.C., et al. J. Biol. Chem. 285(43):32770-32777(2010)Decker, D.A., et al. Neurogastroenterol. Motil. 22(8):901-908(2010)Coddou, C., et al. J. Neurosci. 29(39):12284-12291(2009)Pannek, J., et al. Spinal Cord 47(7):561-564(2009)Chaumont, S., et al. Sci Signal 1 (41), RA8 (2008) :
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