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RAB25 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P57735
Clone Names 101008050
Peptide ID 101008050
Additional Information
Gene ID 57111
Other Names Ras-related protein Rab-25, CATX-8, RAB25, CATX8
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RAB25 (HGNC:18238)
Synonyms CATX8
Function Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia (PubMed:17925226). Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity).
Cellular Location Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, pseudopodium membrane. Cytoplasmic vesicle. Note=Colocalizes with integrin alpha-V/beta-1 in vesicles at the pseudopodial tips
Tissue Location Expressed in ovarian epithelium (NOE) and breast tissue. Expressed in ovarian cancer; expression is increased relative to NOE cells. Expression in ovarian cancer is stage dependent, with stage III and stage IV showing higher levels than early stage cancers. Expressed in breast cancer; expression is increased relative to normal breast tissue
Research Areas
Citations (0)

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RAB proteins, such as RAB25, are members of the RASsuperfamily of small GTPases that are involved in membranetrafficking. Members of the RAB11 subfamily, including RAB25,control the return of internalized membrane-associated moieties tothe cell surface (Caswell et al., 2007 [PubMed 17925226]).[suppliedby OMIM].


Cheng, J.M., et al. Int. J. Cancer 126(12):2799-2812(2010)Nam, K.T., et al. J. Clin. Invest. 120(3):840-849(2010)Caswell, P.T., et al. Dev. Cell 13(4):496-510(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Fan, Y., et al. Pathology 38(6):561-567(2006)

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$ 80.00
Cat# BP16015c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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