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Mouse Axl Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q00993
Clone Names 110316049
Peptide ID 110316049
Additional Information
Gene ID 26362
Other Names Tyrosine-protein kinase receptor UFO, Adhesion-related kinase, Axl, Ark, Ufo
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Axl
Synonyms Ark, Ufo
Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3- kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location In distinct substructures of a broad spectrum of developing tissues (in the late embryogenesis). In cells forming organ capsules as well as in connective tissue structures (in adult)
Research Areas
Citations (0)

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Axl may function as a signal transducer between specific cell types of mesodermal origin.

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$ 80.00
Cat# BP16023a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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