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KANK2 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q63ZY3
Clone Names 100324249
Additional Information
Gene ID 25959
Other Names KN motif and ankyrin repeat domain-containing protein 2, Ankyrin repeat domain-containing protein 25, Matrix-remodeling-associated protein 3, SRC-1-interacting protein, SIP, SRC-interacting protein, SRC1-interacting protein, KANK2, ANKRD25, KIAA1518, MXRA3, SIP
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KANK2
Synonyms ANKRD25, KIAA1518, MXRA3, SIP
Function Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity).
Cellular Location Cytoplasm. Mitochondrion
Tissue Location Strongly expressed in cervix, colon, heart, kidney and lung. Expressed in kidney glomerular podocytes and mesangial cells (at protein level).
Research Areas
Citations (0)
citation

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Background

ANKRD25 contains 5 ANK repeats. It is strongly expressed in cervix, colon, heart, kidney and lung.

References

Zhu, Y., et al. Biochim. Biophys. Acta 1780(2):128-133(2008)Zhang, Y., et al. EMBO J. 26(11):2645-2657(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Wistow, G., et al. Mol. Vis. 8, 205-220 (2002) :

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$ 277.78
Cat# BP16024c
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