|Other Names||Receptor activity-modifying protein 3, Calcitonin-receptor-like receptor activity-modifying protein 3, CRLR activity-modifying protein 3, RAMP3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein Membrane; Single-pass type I membrane protein. Note=Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner|
|Tissue Location||Strongly expressed in lung, breast, immune system and fetal tissues.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the RAMPfamily of single-transmembrane-domain proteins, called receptor(calcitonin) activity modifying proteins (RAMPs). RAMPs are type Itransmembrane proteins with an extracellular N terminus and acytoplasmic C terminus. RAMPs are required to transportcalcitonin-receptor-like receptor (CRLR) to the plasma membrane.CRLR, a receptor with seven transmembrane domains, can function aseither a calcitonin-gene-related peptide (CGRP) receptor or anadrenomedullin receptor, depending on which members of the RAMPfamily are expressed. In the presence of this (RAMP3) protein, CRLRfunctions as an adrenomedullin receptor.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Bailey, R.J., et al. Peptides 31(4):579-584(2010)Harikumar, K.G., et al. Biochemistry 48(49):11773-11785(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Kuwasako, K., et al. Biochem. Biophys. Res. Commun. 377(1):109-113(2008)
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