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RAMP3 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O60896
Clone Names 100525249
Additional Information
Gene ID 10268
Other Names Receptor activity-modifying protein 3, Calcitonin-receptor-like receptor activity-modifying protein 3, CRLR activity-modifying protein 3, RAMP3
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RAMP3
Function Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.
Cellular Location Cell membrane; Single-pass type I membrane protein Membrane; Single-pass type I membrane protein. Note=Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner
Tissue Location Strongly expressed in lung, breast, immune system and fetal tissues.
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene is a member of the RAMPfamily of single-transmembrane-domain proteins, called receptor(calcitonin) activity modifying proteins (RAMPs). RAMPs are type Itransmembrane proteins with an extracellular N terminus and acytoplasmic C terminus. RAMPs are required to transportcalcitonin-receptor-like receptor (CRLR) to the plasma membrane.CRLR, a receptor with seven transmembrane domains, can function aseither a calcitonin-gene-related peptide (CGRP) receptor or anadrenomedullin receptor, depending on which members of the RAMPfamily are expressed. In the presence of this (RAMP3) protein, CRLRfunctions as an adrenomedullin receptor.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Bailey, R.J., et al. Peptides 31(4):579-584(2010)Harikumar, K.G., et al. Biochemistry 48(49):11773-11785(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Kuwasako, K., et al. Biochem. Biophys. Res. Commun. 377(1):109-113(2008)

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$ 277.78
Cat# BP16029b
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