|Other Names||Troponin I, fast skeletal muscle, Troponin I, fast-twitch isoform, TNNI2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.|
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This gene encodes a fast-twitch skeletal muscle protein, amember of the troponin I gene family, and a component of thetroponin complex including troponin T, troponin C and troponin Isubunits. The troponin complex, along with tropomyosin, isresponsible for the calcium-dependent regulation of striated musclecontraction. Mouse studies show that this component is also presentin vascular smooth muscle and may play a role in regulation ofsmooth muscle function. In addition to muscle tissues, this proteinis found in corneal epithelium, cartilage where it is an inhibitorof angiogenesis to inhibit tumor growth and metastasis, and mammarygland where it functions as a co-activator of estrogenreceptor-related receptor alpha. This protein also suppresses tumorgrowth in human ovarian carcinoma. Mutations in this gene causemyopathy and distal arthrogryposis type 2B. Alternatively splicedtranscript variants have been found for this gene. [provided byRefSeq].
Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Perez-Ilzarbe, M., et al. Eur. J. Heart Fail. 10(11):1065-1072(2008)Moran, C.M., et al. Cell Motil. Cytoskeleton 65(8):652-661(2008)Li, Y., et al. Biochem. Biophys. Res. Commun. 369(4):1034-1040(2008)
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