CYGB Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8WWM9 |
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Clone Names | 100525295 |
Gene ID | 114757 |
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Other Names | Cytoglobin, Histoglobin, HGb, Stellate cell activation-associated protein, CYGB, STAP |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CYGB (HGNC:16505) |
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Function | Probable multifunctional globin with a hexacoordinated heme iron required for the catalysis of various reactions depending on redox condition of the cell as well as oxygen availability (PubMed:12359339, PubMed:11893755, PubMed:19147491, PubMed:20511233, PubMed:28671819, PubMed:28393874, PubMed:29128400, PubMed:33576020, PubMed:34930834, PubMed:15165856). Has a nitric oxide dioxygenase (NOD) activity and is most probably involved in cell-mediated and oxygen-dependent nitric oxide consumption (PubMed:19147491, PubMed:20511233, PubMed:28671819, PubMed:28393874). By scavenging this second messenger may regulate several biological processes including endothelium-mediated vasodilation and vascular tone (PubMed:19147491, PubMed:28393874). Under normoxic conditions functions as a nitric oxide dioxygenase (NOD) but under hypoxic conditions the globin may switch its function to that of a nitrite (NO2) reductase (NiR), generating nitric oxide (PubMed:29128400). Could also have peroxidase and superoxide dismutase activities, detoxifying reactive oxygen species and protecting cells against oxidative stress (PubMed:12359339, PubMed:33576020, PubMed:34930834). Also binds dioxygen with low affinity and could function as an oxygen sensor but has probably no function as a respiratory oxygen carrier (PubMed:11893755, PubMed:15299006, PubMed:20553503). |
Cellular Location | Cytoplasm. Nucleus |
Tissue Location | Widely expressed. Highest expression in heart, stomach, bladder and small intestine. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cytoglobin is a ubiquitously expressed hexacoordinatehemoglobin that may facilitate diffusion of oxygen through tissues,scavenge nitric oxide or other reactive oxygen species, or serve aprotective function during oxidative stress (Trent and Hargrove,2002 [PubMed 11893755]).
References
Gardner, A.M., et al. J. Biol. Chem. 285(31):23850-23857(2010)Lechauve, C., et al. FEBS J. 277(12):2696-2704(2010)Shaw, R.J., et al. Br. J. Cancer 101(1):139-144(2009)Halligan, K.E., et al. J. Biol. Chem. 284(13):8539-8547(2009)Ostojic, J., et al. Arch. Ophthalmol. 126(11):1530-1536(2008)
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