|Other Names||Zinc finger protein ZIC 1, Zinc finger protein 201, Zinc finger protein of the cerebellum 1, ZIC1, ZIC, ZNF201|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally- located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'- TGGGTGGTC-3' (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Note=Localizes in the cytoplasm in presence of MDFIC overexpression.|
|Tissue Location||CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined.|
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This gene encodes a member of the ZIC family of C2H2-typezinc finger proteins. Members of this family are important duringdevelopment. Aberrant expression of this gene is seen inmedulloblastoma, a childhood brain tumor. This gene is closelylinked to the gene encoding zinc finger protein of the cerebellum4, a related family member on chromosome 3. This gene encodes atranscription factor that can bind and transactivate theapolipoprotein E gene.
Brill, E., et al. Cancer Res. 70(17):6891-6901(2010)Wang, L.J., et al. Biochem. Biophys. Res. Commun. 379(4):959-963(2009)Baranzini, S.E., et al. Hum. Mol. Genet. 18(4):767-778(2009)Arora, A., et al. RNA 14(7):1290-1296(2008)Pourebrahim, R., et al. FEBS Lett. 581(26):5122-5126(2007)
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