|Other Names||Mitofusin-1, 365-, Fzo homolog, Transmembrane GTPase MFN1, MFN1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.|
|Cellular Location||Mitochondrion outer membrane; Multi- pass membrane protein|
|Tissue Location||Ubiquitous. Expressed at slightly higher level in kidney and heart. Isoform 2 may be overexpressed in some tumors, such as lung cancers.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a mediator ofmitochondrial fusion. This protein and mitofusin 2 are homologs ofthe Drosophila protein fuzzy onion (Fzo). They are mitochondrialmembrane proteins that interact with each other to facilitatemitochondrial targeting.
Perumalsamy, L.R., et al. Proc. Natl. Acad. Sci. U.S.A. 107(15):6882-6887(2010)Park, Y.Y., et al. J. Cell. Sci. 123 (PT 4), 619-626 (2010) :Onoguchi, K., et al. PLoS Pathog. 6 (7), E1001012 (2010) :Waxman, A.B., et al. Am. J. Respir. Cell Mol. Biol. 41(4):385-396(2009)Wolf, C., et al. BMC Med. Genet. 10, 91 (2009) :
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