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MFN1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8IWA4 |
|---|---|
| Clone Names | 100528192 |
| Gene ID | 55669 |
|---|---|
| Other Names | Mitofusin-1, 365-, Fzo homolog, Transmembrane GTPase MFN1, MFN1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MFN1 |
|---|---|
| Function | Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303). Membrane clustering requires GTPase activity (PubMed:27920125). It may involve a major rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376). Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:12759376). Has low GTPase activity (PubMed:27920125, PubMed:28114303). |
| Cellular Location | Mitochondrion outer membrane; Multi-pass membrane protein |
| Tissue Location | Detected in kidney and heart (at protein level) (PubMed:12759376). Ubiquitous (PubMed:11950885, PubMed:12759376) Expressed at slightly higher level in kidney and heart (PubMed:12759376). Isoform 2 may be overexpressed in some tumors, such as lung cancers (PubMed:11751411). |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a mediator ofmitochondrial fusion. This protein and mitofusin 2 are homologs ofthe Drosophila protein fuzzy onion (Fzo). They are mitochondrialmembrane proteins that interact with each other to facilitatemitochondrial targeting.
References
Perumalsamy, L.R., et al. Proc. Natl. Acad. Sci. U.S.A. 107(15):6882-6887(2010)Park, Y.Y., et al. J. Cell. Sci. 123 (PT 4), 619-626 (2010) :Onoguchi, K., et al. PLoS Pathog. 6 (7), E1001012 (2010) :Waxman, A.B., et al. Am. J. Respir. Cell Mol. Biol. 41(4):385-396(2009)Wolf, C., et al. BMC Med. Genet. 10, 91 (2009) :
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