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MFN1 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8IWA4
Clone Names 100528192
Peptide ID 100528192
Additional Information
Gene ID 55669
Other Names Mitofusin-1, 365-, Fzo homolog, Transmembrane GTPase MFN1, MFN1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MFN1
Function Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303). Membrane clustering requires GTPase activity (PubMed:27920125). It may involve a major rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376). Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:12759376). Has low GTPase activity (PubMed:27920125, PubMed:28114303).
Cellular Location Mitochondrion outer membrane; Multi- pass membrane protein
Tissue Location Detected in kidney and heart (at protein level) (PubMed:12759376). Ubiquitous (PubMed:11950885, PubMed:12759376). Expressed at slightly higher level in kidney and heart (PubMed:12759376). Isoform 2 may be overexpressed in some tumors, such as lung cancers (PubMed:11751411)
Research Areas
Citations (0)

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Background

The protein encoded by this gene is a mediator ofmitochondrial fusion. This protein and mitofusin 2 are homologs ofthe Drosophila protein fuzzy onion (Fzo). They are mitochondrialmembrane proteins that interact with each other to facilitatemitochondrial targeting.

References

Perumalsamy, L.R., et al. Proc. Natl. Acad. Sci. U.S.A. 107(15):6882-6887(2010)Park, Y.Y., et al. J. Cell. Sci. 123 (PT 4), 619-626 (2010) :Onoguchi, K., et al. PLoS Pathog. 6 (7), E1001012 (2010) :Waxman, A.B., et al. Am. J. Respir. Cell Mol. Biol. 41(4):385-396(2009)Wolf, C., et al. BMC Med. Genet. 10, 91 (2009) :

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$ 80.00
Cat# BP16037c
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