|Other Names||Heat shock factor protein 4, HSF 4, hHSF4, Heat shock transcription factor 4, HSTF 4, HSF4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription.|
|Tissue Location||Expressed in heart, skeletal muscle, eye and brain, and at much lower levels in some other tissues|
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Provided below are standard protocols that you may find useful for product applications.
Heat-shock transcription factors (HSFs) activateheat-shock response genes under conditions of heat or otherstresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat whichis shared among all vertebrate HSFs and has been suggested to beinvolved in the negative regulation of DNA binding activity. Twoalternatively spliced transcripts encoding distinct isoforms andpossessing different transcriptional activity have been described.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Enoki, Y., et al. Biochim. Biophys. Acta 1802(9):749-753(2010)Ma, Z.Y., et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 26(4):325-328(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Sajjad, N., et al. BMC Med. Genet. 9, 99 (2008) :
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