|Other Names||Heat shock factor protein 4, HSF 4, hHSF4, Heat shock transcription factor 4, HSTF 4, HSF4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription.|
|Tissue Location||Expressed in heart, skeletal muscle, eye and brain, and at much lower levels in some other tissues|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Heat-shock transcription factors (HSFs) activateheat-shock response genes under conditions of heat or otherstresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat whichis shared among all vertebrate HSFs and has been suggested to beinvolved in the negative regulation of DNA binding activity. Twoalternatively spliced transcripts encoding distinct isoforms andpossessing different transcriptional activity have been described.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Enoki, Y., et al. Biochim. Biophys. Acta 1802(9):749-753(2010)Ma, Z.Y., et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 26(4):325-328(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Sajjad, N., et al. BMC Med. Genet. 9, 99 (2008) :
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.