|Other Names||Cell surface glycoprotein CD200 receptor 1, CD200 cell surface glycoprotein receptor, Cell surface glycoprotein OX2 receptor 1, CD200R1, CD200R, CRTR2, MOX2R, OX2R|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CD200R, CRTR2, MOX2R, OX2R|
|Function||Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 2: Secreted.|
|Tissue Location||Expressed in granulocytes, monocytes, most T- cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells.|
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This gene encodes a receptor for the OX-2 membraneglycoprotein. Both the receptor and substrate are cell surfaceglycoproteins containing two immunoglobulin-like domains. Thisreceptor is restricted to the surfaces of myeloid lineage cells andthe receptor-substrate interaction may function as a myeloiddownregulatory signal. Mouse studies of a related gene suggest thatthis interaction may control myeloid function in a tissue-specificmanner. Alternative splicing of this gene results in multipletranscript variants.
Luo, X.G., et al. Neurochem. Res. 35(4):540-547(2010)Mihrshahi, R., et al. J. Immunol. 183(8):4879-4886(2009)Koning, N., et al. J. Neuropathol. Exp. Neurol. 68(2):159-167(2009)Meuth, S.G., et al. J. Neuroimmunol. 194 (1-2), 62-69 (2008) :Wang, X.J., et al. J Neuroimmune Pharmacol 2(3):259-264(2007)
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