|Other Names||Nuclear transcription factor Y subunit gamma, CAAT box DNA-binding protein subunit C, Nuclear transcription factor Y subunit C, NF-YC, Transactivator HSM-1/2, NFYC|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'- CCAAT-3' box motif found in the promoters of its target genes. NF- Y can function as both an activator and a repressor, depending on its interacting cofactors.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes one subunit of a trimeric complexforming a highly conserved transcription factor that binds withhigh specificity to CCAAT motifs in the promoters of a variety ofgenes. The encoded protein, subunit C, forms a tight dimer with theB subunit, a prerequisite for subunit A association. The resultingtrimer binds to DNA with high specificity and affinity. Subunits Band C each contain a histone-like motif. Multiple transcriptvariants encoding different isoforms have been found for this gene.
Ichikawa, S., et al. J. Bone Miner. Res. 25(8):1821-1829(2010)Murai-Takeda, A., et al. J. Biol. Chem. 285(11):8084-8093(2010)Ceribelli, M., et al. J. Biol. Chem. 284(49):34189-34200(2009)Yamanaka, K., et al. Genomics 94(4):219-227(2009)Horikawa, Y., et al. Clin. Cancer Res. 14(23):7956-7962(2008)
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