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NFYC Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q13952 |
|---|---|
| Clone Names | 100528003 |
| Gene ID | 4802 |
|---|---|
| Other Names | Nuclear transcription factor Y subunit gamma, CAAT box DNA-binding protein subunit C, Nuclear transcription factor Y subunit C, NF-YC, Transactivator HSM-1/2, NFYC |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NFYC |
|---|---|
| Function | Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes one subunit of a trimeric complexforming a highly conserved transcription factor that binds withhigh specificity to CCAAT motifs in the promoters of a variety ofgenes. The encoded protein, subunit C, forms a tight dimer with theB subunit, a prerequisite for subunit A association. The resultingtrimer binds to DNA with high specificity and affinity. Subunits Band C each contain a histone-like motif. Multiple transcriptvariants encoding different isoforms have been found for this gene.
References
Ichikawa, S., et al. J. Bone Miner. Res. 25(8):1821-1829(2010)Murai-Takeda, A., et al. J. Biol. Chem. 285(11):8084-8093(2010)Ceribelli, M., et al. J. Biol. Chem. 284(49):34189-34200(2009)Yamanaka, K., et al. Genomics 94(4):219-227(2009)Horikawa, Y., et al. Clin. Cancer Res. 14(23):7956-7962(2008)
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