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NEIL2 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q969S2
Clone Names 100528008
Peptide ID 100528008
Additional Information
Gene ID 252969
Other Names Endonuclease 8-like 2, 322-, DNA glycosylase/AP lyase Neil2, DNA-(apurinic or apyrimidinic site) lyase Neil2, Endonuclease VIII-like 2, Nei homolog 2, NEH2, Nei-like protein 2, NEIL2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NEIL2
Function Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
Cellular Location Nucleus.
Tissue Location Detected in testis, skeletal muscle, heart, brain, placenta, lung, pancreas, kidney and liver
Research Areas
Citations (0)

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NEIL2 belongs to a class of DNA glycosylases homologous tothe bacterial Fpg/Nei family. These glycosylases initiate the firststep in base excision repair by cleaving bases damaged by reactiveoxygen species and introducing a DNA strand break via theassociated lyase reaction (Bandaru et al., 2002 [PubMed12509226])


Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)Monsees, G.M., et al. Breast Cancer Res. Treat. (2010) In press :Grin, I.R., et al. Biochem. Biophys. Res. Commun. 394(1):100-105(2010)Kinslow, C.J., et al. Genes Chromosomes Cancer 47(11):923-932(2008)Zhai, X., et al. Clin. Cancer Res. 14(13):4345-4352(2008)

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$ 80.00
Cat# BP16044a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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