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RPS14 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P62263 |
|---|---|
| Clone Names | 100528016 |
| Gene ID | 6208 |
|---|---|
| Other Names | 40S ribosomal protein S14, RPS14 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RPS14 (HGNC:10387) |
|---|---|
| Function | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). |
| Cellular Location | Cytoplasm. Nucleus, nucleolus |
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Provided below are standard protocols that you may find useful for product applications.
Background
Ribosomes, the organelles that catalyze protein synthesis,consist of a small 40S subunit and a large 60S subunit. Togetherthese subunits are composed of 4 RNA species and approximately 80structurally distinct proteins. This gene encodes a ribosomalprotein that is a component of the 40S subunit. The protein belongsto the S11P family of ribosomal proteins. It is located in thecytoplasm. Transcript variants utilizing alternative transcriptioninitiation sites have been described in the literature. As istypical for genes encoding ribosomal proteins, there are multipleprocessed pseudogenes of this gene dispersed through the genome. InChinese hamster ovary cells, mutations in this gene can lead toresistance to emetine, a protein synthesis inhibitor. Multiplealternatively spliced transcript variants encoding the same proteinhave been found for this gene.
References
Oliva, E.N., et al. Eur. J. Haematol. 85(3):231-235(2010)Borze, I., et al. Cancer Genet. Cytogenet. 197(2):166-173(2010)Quarello, P., et al. Haematologica 95(2):206-213(2010)Valencia, A., et al. Blood 112 (3), 918 (2008) :Ebert, B.L., et al. Nature 451(7176):335-339(2008)
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