|Other Names||60S ribosomal protein L7, RPL7|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.|
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Provided below are standard protocols that you may find useful for product applications.
Ribosomes, the organelles that catalyze protein synthesis,consist of a small 40S subunit and a large 60S subunit. Togetherthese subunits are composed of 4 RNA species and approximately 80structurally distinct proteins. This gene encodes a ribosomalprotein that is a component of the 60S subunit. The protein belongsto the L30P family of ribosomal proteins. It contains an N-terminalbasic region-leucine zipper (BZIP)-like domain and the RNPconsensus submotif RNP2. In vitro the BZIP-like domain mediateshomodimerization and stable binding to DNA and RNA, with apreference for 28S rRNA and mRNA. The protein can inhibit cell-freetranslation of mRNAs, suggesting that it plays a regulatory role inthe translation apparatus. It is located in the cytoplasm. Theprotein has been shown to be an autoantigen in patients withsystemic autoimmune diseases, such as systemic lupus erythematosus.As is typical for genes encoding ribosomal proteins, there aremultiple processed pseudogenes of this gene dispersed through thegenome.
Chou, C.W., et al. FEBS Lett. 584(19):4151-4156(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Maggi, L.B. Jr., et al. Mol. Cell. Biol. 28(23):7050-7065(2008)Robledo, S., et al. RNA 14(9):1918-1929(2008)Wu, W.C., et al. FEBS Lett. 581(4):651-657(2007)
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