|Other Names||Stathmin-2, Superior cervical ganglion-10 protein, Protein SCG10, STMN2, SCG10, SCGN10|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity).|
|Cellular Location||Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone Membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, axon. Golgi apparatus. Endosome. Cell projection, lamellipodium Note=Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms. Colocalized with CIB1 in neurites of developing hippocampal primary neurons (By similarity). Colocalized with CIB1 in the cell body, neuritis and growth cones of neurons. Colocalized with CIB1 to the leading edge of lamellipodia.|
|Tissue Location||Neuron specific.|
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This gene encodes a member of the stathmin family ofphosphoproteins. Stathmin proteins function in microtubule dynamicsand signal transduction. The encoded protein plays a regulatoryrole in neuronal growth and is also thought to be involved inosteogenesis. Reductions in the expression of this gene have beenassociated with Down's syndrome and Alzheimer's disease.Alternatively spliced transcript variants have been observed forthis gene. A pseudogene of this gene is located on the long arm ofchromosome 6.
Paradis, V., et al. Am. J. Pathol. 177(4):1791-1797(2010)Rowe, D.D., et al. Brain Res. (2010) In press :Alves, M.M., et al. Hum. Mol. Genet. 19(18):3642-3651(2010)Xu, H., et al. J. Biol. Chem. 285(6):3548-3553(2010)Mead, S., et al. Lancet Neurol 8(1):57-66(2009)
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