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XPO5 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9HAV4
Clone Names 100528027
Peptide ID 100528027
Additional Information
Gene ID 57510
Other Names Exportin-5, Exp5, Ran-binding protein 21, XPO5, KIAA1291, RANBP21
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name XPO5
Synonyms KIAA1291, RANBP21
Function Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner.
Cellular Location Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm
Tissue Location Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas
Research Areas
Citations (0)

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Exportin-5 belongs to a large family of karyopherins (seeMIM 602738) that mediate the transport of proteins and other cargobetween the nuclear and cytoplasmic compartments.[supplied byOMIM].


Melo, S.A., et al. Cancer Cell 18(4):303-315(2010)Kim, J.S., et al. Mol. Carcinog. 49(10):913-921(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Wilker, E.H., et al. Environ. Health Perspect. 118(7):943-948(2010)Boni, V., et al. Pharmacogenomics J. (2010) In press :

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$ 80.00
Cat# BP16050b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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