|Other Names||RNA-binding protein 10, G patch domain-containing protein 9, RNA-binding motif protein 10, RNA-binding protein S1-1, S1-1, RBM10, DXS8237E, GPATC9, GPATCH9, KIAA0122|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DXS8237E, GPATC9, GPATCH9, KIAA0122|
|Function||May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity).|
|Cellular Location||Nucleus. Note=In the extranucleolar nucleoplasm constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner. Upon globally reducing RNA polymerase II transcription, the nuclear bodies enlarge and decrease in number They occur closely adjacent to nuclear speckles or IGCs (interchromatin granule clusters) but coincide with TIDRs (transcription-inactivation-dependent RNA domains)|
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The protein encoded by this gene contains RNA recognitionmotif found in a variety of RNA binding proteins, including varioushnRNP proteins, proteins implicated in regulation of alternativesplicing, and protein components of snRNPs. In vitro studies showedthat the rat homolog bound to RNA homopolymers, with a preferencefor G and U polyribonucleotides. This gene is part of a genecluster on chromosome Xp11.23, and its 3' end lies within 20 kbupstream of UBE1. Two transcript variants encoding differentisoforms have been identified for this gene.
Johnston, J.J., et al. Am. J. Hum. Genet. 86(5):743-748(2010)Inoue, A., et al. Biol. Cell 100(9):523-535(2008)Dephoure, N., et al. Proc. Natl. Acad. Sci. U.S.A. 105(31):10762-10767(2008)Martin-Garabato, E., et al. Cancer Genomics Proteomics 5 (3-4), 169-173 (2008) :Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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