|Other Names||C4b-binding protein beta chain, C4BPB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.|
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This gene encodes a member of a superfamily of proteinscomposed predominantly of tandemly arrayed short consensus repeatsof approximately 60 amino acids. A single, unique beta-chainencoded by this gene assembles with seven identical alpha-chainsinto the predominant isoform of C4b-binding protein, a multimericprotein that controls activation of the complement cascade throughthe classical pathway. C4b-binding protein has a regulatory role inthe coagulation system also, mediated through the beta-chainbinding of protein S, a vitamin K-dependent protein that serves asa cofactor of activated protein C. The genes encoding both alphaand beta chains are located adjacent to each other on humanchromosome 1 in the regulator of complement activation genecluster. Alternative splicing gives rise to multiple transcriptvariants.
Han, S., et al. Hum. Immunol. 71(7):727-730(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Buil, A., et al. Blood 115(23):4644-4650(2010)Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)
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