CAPG Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P40121 |
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Clone Names | 100528050 |
Gene ID | 822 |
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Other Names | Macrophage-capping protein, Actin regulatory protein CAP-G, CAPG, AFCP, MCP |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CAPG |
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Synonyms | AFCP, MCP |
Function | Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. |
Cellular Location | Nucleus. Cytoplasm Melanosome. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P24452}. Cell projection, ruffle {ECO:0000250|UniProtKB:P24452}. Note=In macrophages, may be predominantly cytoplasmic. Nuclear localization was observed in fibroblasts. In macrophages, present at the membrane-cytoplasm interface. In activated macrophages, concentrated in the ruffles of the leading lamellipodia. {ECO:0000250|UniProtKB:P24452} |
Tissue Location | Macrophages and macrophage-like cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the gelsolin/villin familyof actin-regulatory proteins. The encoded protein reversibly blocksthe barbed ends of F-actin filaments in a Ca2+ andphosphoinositide-regulated manner, but does not sever preformedactin filaments. By capping the barbed ends of actin filaments, theencoded protein contributes to the control of actin-based motilityin non-muscle cells. Alternatively spliced transcript variants havebeen observed, but have not been fully described. [provided byRefSeq].
References
Li, M.X., et al. Med. Oncol. 27(1):134-144(2010)Burillo, E., et al. Atherosclerosis 207(1):32-37(2009)Zhang, R., et al. Am. J. Respir. Cell Mol. Biol. 41(4):467-475(2009)Hubert, T., et al. Biochem. Biophys. Res. Commun. 380(1):166-170(2009)Chen, M., et al. J. Biol. Chem. 284(3):1484-1494(2009)
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