Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.CAPG Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P40121 |
|---|---|
| Clone Names | 100528050 |
| Peptide ID | 100528050 |
| Gene ID | 822 |
|---|---|
| Other Names | Macrophage-capping protein, Actin regulatory protein CAP-G, CAPG, AFCP, MCP |
| Format | Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CAPG |
|---|---|
| Synonyms | AFCP, MCP |
| Function | Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. |
| Cellular Location | Nucleus. Cytoplasm. Secreted {ECO:0000250|UniProtKB:P24452}. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Redistributes throughout the cytoplasm during mitosis and is excluded from regions containing chromosomes (By similarity). {ECO:0000250|UniProtKB:P24452, ECO:0000269|PubMed:17081065} |
| Tissue Location | Macrophages and macrophage-like cells. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abgent.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the gelsolin/villin familyof actin-regulatory proteins. The encoded protein reversibly blocksthe barbed ends of F-actin filaments in a Ca2+ andphosphoinositide-regulated manner, but does not sever preformedactin filaments. By capping the barbed ends of actin filaments, theencoded protein contributes to the control of actin-based motilityin non-muscle cells. Alternatively spliced transcript variants havebeen observed, but have not been fully described. [provided byRefSeq].
References
Li, M.X., et al. Med. Oncol. 27(1):134-144(2010)Burillo, E., et al. Atherosclerosis 207(1):32-37(2009)Zhang, R., et al. Am. J. Respir. Cell Mol. Biol. 41(4):467-475(2009)Hubert, T., et al. Biochem. Biophys. Res. Commun. 380(1):166-170(2009)Chen, M., et al. J. Biol. Chem. 284(3):1484-1494(2009)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abgent.com.
Ordering Information
Other Products
Shipping Information
