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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   CAPG Antibody (Center) Blocking Peptide   

CAPG Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P40121
Clone Names 100528050
Peptide ID 100528050
Additional Information
Gene ID 822
Other Names Macrophage-capping protein, Actin regulatory protein CAP-G, CAPG, AFCP, MCP
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CAPG
Synonyms AFCP, MCP
Function Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.
Cellular Location Nucleus. Cytoplasm. Secreted {ECO:0000250|UniProtKB:P24452}. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Redistributes throughout the cytoplasm during mitosis and is excluded from regions containing chromosomes (By similarity). {ECO:0000250|UniProtKB:P24452, ECO:0000269|PubMed:17081065}
Tissue Location Macrophages and macrophage-like cells.
Research Areas
Citations (0)

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Background

This gene encodes a member of the gelsolin/villin familyof actin-regulatory proteins. The encoded protein reversibly blocksthe barbed ends of F-actin filaments in a Ca2+ andphosphoinositide-regulated manner, but does not sever preformedactin filaments. By capping the barbed ends of actin filaments, theencoded protein contributes to the control of actin-based motilityin non-muscle cells. Alternatively spliced transcript variants havebeen observed, but have not been fully described. [provided byRefSeq].

References

Li, M.X., et al. Med. Oncol. 27(1):134-144(2010)Burillo, E., et al. Atherosclerosis 207(1):32-37(2009)Zhang, R., et al. Am. J. Respir. Cell Mol. Biol. 41(4):467-475(2009)Hubert, T., et al. Biochem. Biophys. Res. Commun. 380(1):166-170(2009)Chen, M., et al. J. Biol. Chem. 284(3):1484-1494(2009)

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$ 80.00
Cat# BP16057c
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