|Other Names||Macrophage-capping protein, Actin regulatory protein CAP-G, CAPG, AFCP, MCP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.|
|Cellular Location||Cytoplasm. Nucleus. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
|Tissue Location||Macrophages and macrophage-like cells.|
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This gene encodes a member of the gelsolin/villin familyof actin-regulatory proteins. The encoded protein reversibly blocksthe barbed ends of F-actin filaments in a Ca2+ andphosphoinositide-regulated manner, but does not sever preformedactin filaments. By capping the barbed ends of actin filaments, theencoded protein contributes to the control of actin-based motilityin non-muscle cells. Alternatively spliced transcript variants havebeen observed, but have not been fully described. [provided byRefSeq].
Li, M.X., et al. Med. Oncol. 27(1):134-144(2010)Burillo, E., et al. Atherosclerosis 207(1):32-37(2009)Zhang, R., et al. Am. J. Respir. Cell Mol. Biol. 41(4):467-475(2009)Hubert, T., et al. Biochem. Biophys. Res. Commun. 380(1):166-170(2009)Chen, M., et al. J. Biol. Chem. 284(3):1484-1494(2009)
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