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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   MRC2 Antibody (Center) Blocking Peptide   

MRC2 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9UBG0
Clone Names 100528054
Peptide ID 100528054
Additional Information
Gene ID 9902
Other Names C-type mannose receptor 2, C-type lectin domain family 13 member E, Endocytic receptor 180, Macrophage mannose receptor 2, Urokinase-type plasminogen activator receptor-associated protein, UPAR-associated protein, Urokinase receptor-associated protein, CD280, MRC2, CLEC13E, ENDO180, KIAA0709, UPARAP
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MRC2
Synonyms CLEC13E, ENDO180, KIAA0709, UPARAP
Function May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon Expressed in endothelial cells, fibroblasts and macrophages Highly expressed in fetal lung and kidney
Research Areas
Citations (0)

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Background

MRC2 is a recycling endocytic receptor that functions incell motility and remodeling of the extracellular matrix bypromoting cell migration and uptake of collagens for intracellulardegradation (Wienke et al., 2007 [PubMed 17974964]).[supplied byOMIM].

References

Messaritou, G., et al. J. Cell. Sci. 122 (PT 22), 4042-4048 (2009) :Wu, X., et al. Cancer Prev Res (Phila Pa) 2(7):617-624(2009)Wienke, D., et al. Cancer Res. 67(21):10230-10240(2007)Sulek, J., et al. J. Histochem. Cytochem. 55(4):347-353(2007)Johnson, J.M., et al. Science 302(5653):2141-2144(2003)

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$ 80.00
Cat# BP16060c
Size:
Quantity:
(40 western blots)
Availability: In Stock
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