|Other Names||C-type mannose receptor 2, C-type lectin domain family 13 member E, Endocytic receptor 180, Macrophage mannose receptor 2, Urokinase-type plasminogen activator receptor-associated protein, UPAR-associated protein, Urokinase receptor-associated protein, CD280, MRC2, CLEC13E, ENDO180, KIAA0709, UPARAP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CLEC13E, ENDO180, KIAA0709, UPARAP|
|Function||May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon Expressed in endothelial cells, fibroblasts and macrophages Highly expressed in fetal lung and kidney|
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MRC2 is a recycling endocytic receptor that functions incell motility and remodeling of the extracellular matrix bypromoting cell migration and uptake of collagens for intracellulardegradation (Wienke et al., 2007 [PubMed 17974964]).[supplied byOMIM].
Messaritou, G., et al. J. Cell. Sci. 122 (PT 22), 4042-4048 (2009) :Wu, X., et al. Cancer Prev Res (Phila Pa) 2(7):617-624(2009)Wienke, D., et al. Cancer Res. 67(21):10230-10240(2007)Sulek, J., et al. J. Histochem. Cytochem. 55(4):347-353(2007)Johnson, J.M., et al. Science 302(5653):2141-2144(2003)
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