|Other Names||SLAM family member 6, Activating NK receptor, NK-T-B-antigen, NTB-A, CD352, SLAMF6, KALI|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a type I transmembraneprotein, belonging to the CD2 subfamily of the immunoglobulinsuperfamily. This encoded protein is expressed on Natural killer(NK), T, and B lymphocytes. It undergoes tyrosine phosphorylationand associates with the Src homology 2 domain-containing protein(SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs).It functions as a coreceptor in the process of NK cell activation.It can also mediate inhibitory signals in NK cells from X-linkedlymphoproliferative patients. Alternative splicing results inmultiple transcript variants encoding distinct isoforms.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Davila, S., et al. Genes Immun. 11(3):232-238(2010)Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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