|Other Names||Sorting nexin-17, SNX17, KIAA0064|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).|
|Cellular Location||Cytoplasm. Early endosome. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the sorting nexin family.Members of this family contain a phox (PX) domain, which is aphosphoinositide binding domain, and are involved in intracellulartrafficking. This protein does not contain a coiled coil region,like some family members, but contains a B41 domain. This proteininteracts with the cytoplasmic domain of P-selectin, and mayfunction in the intracellular trafficking of P-selectin. [providedby RefSeq].
Lee, J., et al. J. Biol. Chem. 283(17):11501-11508(2008)Wu, C., et al. Proteomics 7(11):1775-1785(2007)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Czubayko, M., et al. Biochem. Biophys. Res. Commun. 345(3):1264-1272(2006)van Kerkhof, P., et al. EMBO J. 24(16):2851-2861(2005)
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