|Other Names||Peripheral myelin protein 22, PMP-22, Growth arrest-specific protein 3, GAS-3, Pmp22, Gas-3, Gas3, Pmp-22|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||Gas-3, Gas3, Pmp-22|
|Function||Might be involved in growth regulation, and in myelinization in the peripheral nervous system.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Schwann cells of the peripheral nervous system|
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This gene encodes an integral membrane protein that is amajor component of myelin in the peripheral nervous system. Variousmutations of this gene are causes of Charcot-Marie-Tooth diseaseType IA, Dejerine-Sottas syndrome, and hereditary neuropathy withliability to pressure palsies.
Sahenk, Z., et al. Exp. Neurol. 224(2):495-506(2010)Coulpier, F., et al. J. Neurosci. 30(17):5958-5967(2010)Bai, Y., et al. J. Neurosci. 30(2):600-608(2010)Bremer, J., et al. PLoS ONE 5 (8), E12450 (2010) :Grossmann, K.S., et al. Proc. Natl. Acad. Sci. U.S.A. 106(39):16704-16709(2009)
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