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GATA3 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P23771 |
|---|---|
| Clone Names | 100430083 |
| Gene ID | 2625 |
|---|---|
| Other Names | Trans-acting T-cell-specific transcription factor GATA-3, GATA-binding factor 3, GATA3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GATA3 |
|---|---|
| Function | Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (By similarity). Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages. |
| Cellular Location | Nucleus. |
| Tissue Location | T-cells and endothelial cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein which belongs to the GATAfamily of transcription factors. The protein contains two GATA-typezinc fingers and is an important regulator of T-cell developmentand plays an important role in endothelial cell biology. Defects inthis gene are the cause of hypoparathyroidism with sensorineuraldeafness and renal dysplasia.
References
Cook, K.D., et al. J. Immunol. 185(6):3209-3216(2010)Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)Kemp, K.L., et al. J. Immunol. 184(8):4178-4184(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Yao, X., et al. Chin. Med. J. 123(6):739-744(2010)
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