|Other Names||Trans-acting T-cell-specific transcription factor GATA-3, GATA-binding factor 3, GATA3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses.|
|Tissue Location||T-cells and endothelial cells.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein which belongs to the GATAfamily of transcription factors. The protein contains two GATA-typezinc fingers and is an important regulator of T-cell developmentand plays an important role in endothelial cell biology. Defects inthis gene are the cause of hypoparathyroidism with sensorineuraldeafness and renal dysplasia.
Cook, K.D., et al. J. Immunol. 185(6):3209-3216(2010)Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)Kemp, K.L., et al. J. Immunol. 184(8):4178-4184(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Yao, X., et al. Chin. Med. J. 123(6):739-744(2010)
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