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LIG3 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P49916
Clone Names 100507266
Peptide ID 100507266
Additional Information
Gene ID 3980
Other Names DNA ligase 3, DNA ligase III, Polydeoxyribonucleotide synthase [ATP] 3, LIG3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name LIG3
Function Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand- break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627).
Cellular Location Isoform 1: Mitochondrion Note=Contains an N-terminal mitochondrial transit peptide Isoform 3: Nucleus. Note=Lacks the N-terminal mitochondrial transit peptide.
Tissue Location Testis, thymus, prostate and heart.
Research Areas
Citations (0)

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This gene is a member of the DNA ligase family. Eachmember of this family encodes a protein that catalyzes the joiningof DNA ends but they each have a distinct role in DNA metabolism.The protein encoded by this gene is involved in excision repair andis located in both the mitochondria and nucleus, with translationinitiation from the upstream start codon allowing for transport tothe mitochondria and translation initiation from a downstream startcodon allowing for transport to the nucleus. Additionally,alternate transcriptional splice variants, encoding differentisoforms, have been characterized.


Wang, W., et al. Nucleic Acids Res. (2010) In press :Arora, M., et al. Leukemia 24(8):1470-1475(2010)Cotner-Gohara, E., et al. Biochemistry 49(29):6165-6176(2010)Ho-Pun-Cheung, A., et al. Pharmacogenomics J. (2010) In press :Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)

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$ 80.00
Cat# BP16089b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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