|Other Names||DNA ligase 3, DNA ligase III, Polydeoxyribonucleotide synthase [ATP] 3, LIG3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand- break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627).|
|Cellular Location||Isoform 1: Mitochondrion Note=Contains an N-terminal mitochondrial transit peptide Isoform 3: Nucleus. Note=Lacks the N-terminal mitochondrial transit peptide.|
|Tissue Location||Testis, thymus, prostate and heart.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the DNA ligase family. Eachmember of this family encodes a protein that catalyzes the joiningof DNA ends but they each have a distinct role in DNA metabolism.The protein encoded by this gene is involved in excision repair andis located in both the mitochondria and nucleus, with translationinitiation from the upstream start codon allowing for transport tothe mitochondria and translation initiation from a downstream startcodon allowing for transport to the nucleus. Additionally,alternate transcriptional splice variants, encoding differentisoforms, have been characterized.
Wang, W., et al. Nucleic Acids Res. (2010) In press :Arora, M., et al. Leukemia 24(8):1470-1475(2010)Cotner-Gohara, E., et al. Biochemistry 49(29):6165-6176(2010)Ho-Pun-Cheung, A., et al. Pharmacogenomics J. (2010) In press :Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)
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