|Other Names||Pre-mRNA-processing factor 6, Androgen receptor N-terminal domain-transactivating protein 1, ANT-1, PRP6 homolog, U5 snRNP-associated 102 kDa protein, U5-102 kDa protein, PRPF6, C20orf14|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in pre-mRNA splicing as component of the U4/U6- U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.|
|Cellular Location||Nucleus, nucleoplasm. Nucleus speckle. Note=Localized in splicing speckles|
|Tissue Location||Widely expressed.|
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PRPF6 is involved in pre-mRNA splicing. May act in the tri-snRNP complex as a bridging factor between U5 and U4/U6 snRNPs in the late step of spliceosome assembly. May be necessary for tri-snRNP formation.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Schneider, M., et al. Nat. Struct. Mol. Biol. 17(2):216-221(2010)Su, L., et al. J. Huazhong Univ. Sci. Technol. Med. Sci. 28(1):97-101(2008)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Fan, S., et al. Biochem. Biophys. Res. Commun. 341(1):192-201(2006)
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