|Other Names||Vacuolar protein sorting-associated protein 45, h-VPS45, hlVps45, VPS45, VPS45A, VPS45B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network.|
|Cellular Location||Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein Note=Associated with Golgi/endosomal vesicles and the trans-Golgi network.|
|Tissue Location||Ubiquitous. Expression was highest in testis, heart and brain, intermediate in kidney, spleen, prostate, ovary, small intestine and thymus and low in lung, skeletal muscle, placenta, colon, pancreas, peripheral blood leukocytes and liver|
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Vesicle mediated protein sorting plays an important rolein segregation of intracellular molecules into distinct organelles.Genetic studies in yeast have identified more than 40 vacuolarprotein sorting (VPS) genes involved in vesicle transport tovacuoles. This gene is a member of the Sec1 domain family, andshows a high degree of sequence similarity to mouse, rat and yeastVps45. The exact function of this gene is not known, but its highexpression in peripheral blood mononuclear cells suggests a role intrafficking proteins, including inflammatory mediators. [providedby RefSeq].
Rahajeng, J., et al. Exp. Cell Res. 316(5):859-874(2010)Kim, B.Y., et al. Biochem. Biophys. Res. Commun. 311(3):577-582(2003)Dulubova, I., et al. EMBO J. 21(14):3620-3631(2002)de Renzis, S., et al. Nat. Cell Biol. 4(2):124-133(2002)Nielsen, E., et al. J. Cell Biol. 151(3):601-612(2000)
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