|Other Names||Orexin receptor type 1, Ox-1-R, Ox1-R, Ox1R, Hypocretin receptor type 1, HCRTR1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide (PubMed:9491897, PubMed:26950369). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a G-protein coupledreceptor involved in the regulation of feeding behavior. Theencoded protein selectively binds the hypothalamic neuropeptideorexin A. A related gene (HCRTR2) encodes a G-protein coupledreceptor that binds orexin A and orexin B.
Peltonen, H.M., et al. Biochim. Biophys. Acta 1803(10):1206-1212(2010)Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :Turunen, P.M., et al. Br. J. Pharmacol. 159(1):212-221(2010)El Firar, A., et al. FASEB J. 23(12):4069-4080(2009)
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