|Other Names||SEC14-like protein 2, Alpha-tocopherol-associated protein, TAP, hTAP, Squalene transfer protein, Supernatant protein factor, SPF, SEC14L2, C22orf6, KIAA1186, KIAA1658|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||C22orf6, KIAA1186, KIAA1658|
|Function||Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.|
|Cellular Location||Cytoplasm. Nucleus. Note=Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha- tocopherol|
|Tissue Location||Widely expressed. Strong expression in liver, brain and prostate.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a cytosolic protein which belongs to afamily of lipid-binding proteins including Sec14p, alpha-tocopheroltransfer protein, and cellular retinol-binding protein. The encodedprotein stimulates squalene monooxygenase which is a downstreamenzyme in the cholesterol biosynthetic pathway. Alternativelyspliced transcript variants encoding different isoforms have beenidentified for this gene.
Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)Wang, X., et al. Cancer Invest. 27(10):971-977(2009)Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)Johnykutty, S., et al. Mod. Pathol. 22(6):770-775(2009)Wright, M.E., et al. Cancer Res. 69(4):1429-1438(2009)
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