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SEC14L2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O76054 |
|---|---|
| Clone Names | 100525306 |
| Gene ID | 23541 |
|---|---|
| Other Names | SEC14-like protein 2, Alpha-tocopherol-associated protein, TAP, hTAP, Squalene transfer protein, Supernatant protein factor, SPF, SEC14L2, C22orf6, KIAA1186, KIAA1658 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SEC14L2 |
|---|---|
| Synonyms | C22orf6, KIAA1186, KIAA1658 |
| Function | Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha- tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell. |
| Cellular Location | Cytoplasm. Nucleus. Note=Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha-tocopherol |
| Tissue Location | Widely expressed. Strong expression in liver, brain and prostate. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a cytosolic protein which belongs to afamily of lipid-binding proteins including Sec14p, alpha-tocopheroltransfer protein, and cellular retinol-binding protein. The encodedprotein stimulates squalene monooxygenase which is a downstreamenzyme in the cholesterol biosynthetic pathway. Alternativelyspliced transcript variants encoding different isoforms have beenidentified for this gene.
References
Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)Wang, X., et al. Cancer Invest. 27(10):971-977(2009)Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)Johnykutty, S., et al. Mod. Pathol. 22(6):770-775(2009)Wright, M.E., et al. Cancer Res. 69(4):1429-1438(2009)
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