|Other Names||WD repeat-containing protein 5, BMP2-induced 3-kb gene protein, WDR5, BIG3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.|
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This gene encodes a member of the WD repeat proteinfamily. WD repeats are minimally conserved regions of approximately40 amino acids typically bracketed by gly-his and trp-asp (GH-WD),which may facilitate formation of heterotrimeric or multiproteincomplexes. Members of this family are involved in a variety ofcellular processes, including cell cycle progression, signaltransduction, apoptosis, and gene regulation. This protein contains7 WD repeats. Alternatively spliced transcript variants encodingthe same protein have been identified.
Davis, O.S., et al. Behav. Genet. 40(6):759-767(2010)Yates, J.A., et al. FEBS Lett. 584(4):689-693(2010)Cai, Y., et al. J. Biol. Chem. 285(7):4268-4272(2010)Wang, Y.Y., et al. Proc. Natl. Acad. Sci. U.S.A. 107(2):815-820(2010)Patel, A., et al. J. Biol. Chem. 284(36):24242-24256(2009)
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