|Other Names||Tax1-binding protein 1, TRAF6-binding protein, TAX1BP1, T6BP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.|
|Tissue Location||Expressed in all tissues tested.|
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Provided below are standard protocols that you may find useful for product applications.
The HTLV-1 Tax protein transcriptionally activates theHTLV-1 promoter. Tax also binds to and stimulates the expression ofcellular genes, including transcription factors and other proteins(Gachon et al., 1998 [PubMed 9733879]).
Parvatiyar, K., et al. J. Biol. Chem. 285(20):14999-15009(2010)Ruiz, M.T., et al. Braz J Otorhinolaryngol 76(2):193-198(2010)Shembade, N., et al. Science 327(5969):1135-1139(2010)Dieguez-Gonzalez, R., et al. Ann. Rheum. Dis. 68(4):579-583(2009)Shembade, N., et al. EMBO J. 28(5):513-522(2009)
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