|Other Names||NADPH:adrenodoxin oxidoreductase, mitochondrial, AR, Adrenodoxin reductase, Ferredoxin--NADP(+) reductase, Ferredoxin reductase, FDXR, ADXR|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.|
|Cellular Location||Mitochondrion matrix.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a mitochondrial flavoprotein thatinitiates electron transport for cytochromes P450 receivingelectrons from NADPH. Multiple alternatively spliced transcriptvariants of this gene have been described although the full-lengthnature of only two that encode different isoforms have beendetermined.
Trapasso, F., et al. J. Biol. Chem. 283(20):13736-13744(2008)Araya, Z., et al. Biochim. Biophys. Acta 1632 (1-3), 40-47 (2003) :Thiboutot, D., et al. J. Invest. Dermatol. 120(6):905-914(2003)Liu, G., et al. Oncogene 21(47):7195-7204(2002)Coghlan, V.M., et al. J. Biol. Chem. 266(28):18606-18612(1991)
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